Frequency and Accuracy of Anti-Citrullinated Protein Antibodies, Prognostic Evaluation in Overall Developing to Erosive Disease in Patients with Psoriatic Seronegative Osteoarthropathy

Anti-cyclic peptide antibodies (CCP/ACPA) are directed towards synthetic citrullinated peptides and are specific markers in diagnosis of Rheumatoid arthritis. This study aimed to compare the values and acuracy of the test in anticyclic citrullinated peptides (Anti-CCP /ACPA) antibodies, rheumatoid factor (RF), C-reactive protein (CRP) and disease activity index (PASI) in early diagnosis of untreated psoriatic arthritis (PsA). Using the ELISA method, sera of 70 participants were examined (35 untreated PsA patients and 35 healthy controls). RF and CRP were determined with the agglutination test. At the same time, the sensitivity, specificity, predictive value for positive and negative test, and accuracy were determined. From 35 PsA patients, 1 patient showed presence of Anti-CCP antibodies (sensitivity test 2.86%), while RF was not detected (sensitivity test 0%). In the healthy control group positive values for RF, CRP and erythroid sedimentation rate were detected in 1 participant. Therefore, ACPA antibodies have low sensitivity, but high specificity in PsA.